کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1935910 1050677 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bile acid regulates c-Jun expression through the orphan nuclear receptor SHP induction in gastric cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Bile acid regulates c-Jun expression through the orphan nuclear receptor SHP induction in gastric cells
چکیده انگلیسی

Bile reflux is considered to be one of the most important causative factors in gastric carcinogenesis, due to the attendant inflammatory changes in the gastric mucosa. In this study, we have assessed the molecular mechanisms inherent to the contribution of bile acid to the transcriptional regulation of inflammatory-related genes. In this study, we demonstrated that bile acid induced the expression of the SHP orphan nuclear receptor at the transcriptional level via c-Jun activation. Bile acid also enhanced the protein interaction of NF-κB and SHP, thereby resulting in an increase in c-Jun expression and the production of the inflammatory cytokine, TNFα. These results indicate that bile acid performs a critical function in the regulation of the induction of inflammatory-related genes in gastric cells, and that bile acid-mediated gene expression provides a pre-clue for the development of gastric cellular malformation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 369, Issue 2, 2 May 2008, Pages 437–443
نویسندگان
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