کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1935978 | 1050680 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prolonged modulation of FGF-2 expression in astrocytic cultures induced by O,O′-diacetyl-apomorphine Prolonged modulation of FGF-2 expression in astrocytic cultures induced by O,O′-diacetyl-apomorphine](/preview/png/1935978.png)
Apomorphine (APO) is an anti-parkinsonian drug currently in use, which provides relief of Parkinson’s symptoms. However, the utility of APO is greatly hampered by its poor bioavailability and rapid metabolism. In the present study, O,O′-diacetyl-apomorphine, a prodrug of apomorphine, was synthesized and its biological activity was examined. The prodrug induced fibroblast growth factor-2 production in astrocytic cultures similarly to apomorphine. However, its duration of action was significantly prolonged, and its resistance to oxidation was markedly enhanced compared to APO. O,O′-Diacetyl-apomorphine also induced MEK/MAPK signaling. These results suggest that O,O′-diacetyl-apomorphine can efficiently counteract oxidation and thereby enhance FGF-2 production in astrocytes.
Journal: Biochemical and Biophysical Research Communications - Volume 369, Issue 3, 9 May 2008, Pages 824–829