کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1936815 1050703 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives
چکیده انگلیسی

Collectrin is a type I membrane protein and shares significant homology with C-terminal domain of angiotensin-converting enzyme-2 (ACE2). However, collectrin lacks catalytic domain and it suggests the presence of uncharacterized physiological functions of collectrin. Collectrin is transcriptionally regulated by hepatocyte nuclear factor-α and -β and is highly expressed on renal proximal tubules and collecting ducts as well as pancreatic β-cells. Recent in vitro and in vivo studies demonstrated interesting physiological roles of collectrin related to insulin secretion, formation of primary cilia, renal cyst formation and amino acid transport. The common underlying molecular mechanism may be suggested by the evidence that collectrin binds to SNARE complex by interacting with snapin. Collectrin is involved in the process of vesicle transport and membrane fusion and thus it delivers insulin for exocytosis or various membrane proteins to apical plasmalemma and primary cilia. Collectrin may be the new therapeutic target for various pathological processes such as diabetes, polycystic kidney disease, hypertension and aminoaciduria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 363, Issue 1, 9 November 2007, Pages 1–5
نویسندگان
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