کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1936999 | 1050706 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Angiotensin II protects against α-synuclein toxicity and reduces protein aggregation in vitro Angiotensin II protects against α-synuclein toxicity and reduces protein aggregation in vitro](/preview/png/1936999.png)
In this study, we examined the effects of angiotensin II (AngII) in a genetic in vitro PD model produced by α-synuclein (α-syn) overexpression in the human neuroglioma H4 cell line. We observed a maximal decrease in α-syn-induced toxicity of 85% and reduction in inclusion formation by 19% when cultures were treated with AngII in the presence of the angiotensin type 1 (AT1) receptor antagonist losartan and AT2 receptor antagonist PD123319. When compared to AngII, the AT4 receptor agonist AngIV was moderately effective in protecting H4 cells against α-syn toxicity and did not significantly reduce inclusion formation. Here we show that AngII is protective against genetic, as well as neurotoxic models of PD. These data support the view that agents acting on the renin–angiotensin-system (RAS) may be useful in the prevention and/or treatment of Parkinson’s disease.
Journal: Biochemical and Biophysical Research Communications - Volume 363, Issue 3, 23 November 2007, Pages 846–851