کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1937451 1050716 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design
چکیده انگلیسی

Cytochrome P450 2C19 (CYP2C19) is a member of the cytochrome P-450 enzyme superfamily and plays an important role in the metabolism of drugs. In order to gain insights for developing personalized drugs, the 3D (dimensional) structure of CYP2C19 has been developed based on the crystal structure of CYP2C9 (PDB code 1R90), and its structure–activity relationship with the ligands of CEC, Fluvoxamine, Lescol, and Ticlopidine investigated through the structure–activity relationship approach. By means of a series of docking studies, the binding pockets of CYP2C19 for the four compounds are explicitly defined that will be very useful for conducting mutagenesis studies, providing insights into personalization of drug treatments and stimulating novel strategies for finding desired personalized drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 355, Issue 2, 6 April 2007, Pages 513–519
نویسندگان
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