کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1937539 | 1050719 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress](/preview/png/1937539.png)
چکیده انگلیسی
Recent studies have established that erythropoietin (EPO) is a pleiotropic cytokine. In this study we investigated whether pleiotropic effects of EPO may involve regulation of heme oxygenase (HO)-1, an anti-oxidative stress protein. A stimulatory effect of EPO on HO-1 expression was demonstrated in cultured renal endothelial cells, in which EPO decreased intracellular oxidative stress and provided cytoprotection against H2O2. These beneficial effects were partially reversed by a HO-1 inhibitor. We then evaluated whether EPO induces HO-1 and ameliorates renal injury in vivo. Administration of EPO to Dahl salt-sensitive (DS) rats with low salt diet, a model of chronic tubulointerstitial injury, reduced proteinuria, and renal injury including peritubular capillaries rarefaction as compared to vehicle-treated DS rats. This renoprotection was associated with up-regulation of HO-1 in the kidney. In conclusion, EPO-induced HO-1 expression is likely to provide cytoprotection against oxidative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 359, Issue 4, 10 August 2007, Pages 928-934
Journal: Biochemical and Biophysical Research Communications - Volume 359, Issue 4, 10 August 2007, Pages 928-934
نویسندگان
Pisut Katavetin, Reiko Inagi, Toshio Miyata, Jing Shao, Ryoji Sassa, Stephen Adler, Nobuaki Eto, Hideki Kato, Toshiro Fujita, Masaomi Nangaku,