کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1937641 | 1050722 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neighboring-site effects of amino acid mutation
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neighboring-site effects of amino acid mutation Neighboring-site effects of amino acid mutation](/preview/png/1937641.png)
چکیده انگلیسی
Although the context dependence of nucleotide mutation has been supported by accumulating theoretical and experimental evidence, whether this effect can be extended to amino acid mutation remains obscure. As the amino acid doublets (20Â ÃÂ 20) are much more diverse than their nucleotide counterparts (4Â ÃÂ 4), any attempt to address the neighboring-site effects of amino acid mutation was frustrated by deficient amino acid mutation data. Based on the recently revealed 599,745 mutation sites in 45,137 orthologous proteins, we provide solid evidence for the first time to support the existence of neighboring-site effects in amino acid mutation, which is significantly important to improving the prevalent protein-evolution models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 353, Issue 3, 16 February 2007, Pages 531-534
Journal: Biochemical and Biophysical Research Communications - Volume 353, Issue 3, 16 February 2007, Pages 531-534
نویسندگان
Guang-Zhong Wang, Ling-Ling Chen, Hong-Yu Zhang,