کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1937726 1050724 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reversine stimulates adipocyte differentiation and downregulates Akt and p70s6k signaling pathways in 3T3-L1 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Reversine stimulates adipocyte differentiation and downregulates Akt and p70s6k signaling pathways in 3T3-L1 cells
چکیده انگلیسی

In this study, we investigate the ability of reversine to stimulate adipocyte differentiation and its effect on cellular signaling pathways associated with adipocyte differentiation. Our data show that reversine treatment of 3T3-L1 cells under differentiation conditions synergistically enhances adipocyte differentiation and the expression of adipogenic marker genes such as aP2, PPAR-γ, resistin, C/EBPα, and adiponectin. In parallel, reversine treatment leads to a selective downregulation of Akt and p70s6k signaling pathways, but not the ERK pathway. Furthermore, reversine stimulation of adipocyte differentiation seems to be quite different from troglitazone’s action, because reversine treatment does not induce the transcriptional activation of PPAR-γ and troglitazone does not affect the Akt and p70s6k signaling pathways. Taken together, our data clearly demonstrate the ability of reversine to stimulate adipocyte differentiation, which is independent of the Akt and p70s6k signaling pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 358, Issue 2, 29 June 2007, Pages 553–558
نویسندگان
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