کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1937927 | 1050728 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Persistent tetrodotoxin-resistant Na+ currents are activated by prostaglandin E2 via cyclic AMP-dependent pathway in C-type nodose neurons of adult rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
It has been documented that nodose neurons express TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) Na+ channels. However, wheteher nodose neurons functionally express persistent TTX-R Na+ currents has not been reported. The present study first demonstrated persistent TTX-R Na+ channel activities in 7/19 C-type nodose neurons in the presence of PGE2 using whole-cell patch. Voltage-dependent property showed that persistent TTX-R Na+ currents were activated at near â60Â mV and channels were maintained open. The average peak was approximately 300-500Â pA. The mid-point of activation exhibited a greater shift to a more hyperpolarized potential in the neurons co-expressing TTX-R and persistent TTX-R Na+ currents than those expressing TTX-R only. This effect of PGE2 was also mimicked by Forskolin. The fact that persistent TTX-R Na+ currents were only activated by PGE2 suggested that the modulatory effects of PGE2 on persistent TTX-R Na+ currents are crucial in PGE2-mediated neuronal excitability, and may have a great impact on specifically physiological significance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 355, Issue 4, 20 April 2007, Pages 1064-1068
Journal: Biochemical and Biophysical Research Communications - Volume 355, Issue 4, 20 April 2007, Pages 1064-1068
نویسندگان
Baiyan Li, John H. Schild,