کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1937979 1050729 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differences in two mice strains on kainic acid-induced amygdalar seizures
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Differences in two mice strains on kainic acid-induced amygdalar seizures
چکیده انگلیسی

Seizure susceptibility and neurodegeneration induced by microinjection of kainic acid (KA) into the left amygdala (LA) in C57BL/6 and FVB/N mouse strains were compared. Mice were administered 0.5 μg of KA into the LA. Electroencephalograms (EEGs) and behavior were monitored for 48 h after KA microinjection. Neuronal cell damages in the CA1 and CA3 regions of hippocampus were assessed at 2 and 48 h after KA microinjection. We demonstrated that the FVB/N mice showed longer duration of seizure activity than the C57BL/6 mice in EEGs and behavioral observation. The C57BL/6 mice were resistant to neurodegeneration while the FVB/N mice were vulnerable as measured 2 and 48 h after KA microinjection. These differences might be associated with genetic background.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 357, Issue 4, 15 June 2007, Pages 1078–1083
نویسندگان
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