کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1938016 | 1050730 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse](/preview/png/1938016.png)
The role of the adventitia in vascular function and vascular lesion formation has been largely ignored. This study observed the activation of the adventitia and specifically the fibroblasts in the development of atherosclerosis in the apoE(−/−) mouse. The results showed a gradual increase in expression of collagen types I and III after 2, 4, and 8 weeks of hyperlipidic diet. The earliest expression of monocyte chemoattractant protein-1 (MCP-1) protein and mRNA was detected in the adventitial fibroblast before the formation of intimal lesions. Proliferation, too, was first found in the adventitial fibroblasts. We hypothesize that the adventitial fibroblast is activated in the early stage of atherosclerosis. Adventitial inflammation may be an early event in the development of atherosclerotic lesions.
Journal: Biochemical and Biophysical Research Communications - Volume 352, Issue 3, 19 January 2007, Pages 681–688