کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1938163 | 1050734 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resveratrol inhibits firefly luciferase
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The potential therapeutic value of resveratrol in age-related disease settings including cancer, diabetes, and Alzheimer’s has emerged from a rapidly growing body of experimental evidence. Protection from oxidative stress appears to be a common feature of resveratrol that may be mediated through SirT1, though more specific molecular mechanisms by which resveratrol mediates its effects remain unclear. This has prompted an upsurge in cell-based mechanistic studies, often incorporating reporter assays for pathway elucidation in response to resveratrol treatment. Here, we report that resveratrol potently inhibits firefly luciferase with a Ki value of 2 μM, and caution that this confounding element may lead to compromised data interpretation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 351, Issue 2, 15 December 2006, Pages 481–484
Journal: Biochemical and Biophysical Research Communications - Volume 351, Issue 2, 15 December 2006, Pages 481–484
نویسندگان
Adel Bakhtiarova, Paul Taslimi, Stephen J. Elliman, Penelope A. Kosinski, Brian Hubbard, Michael Kavana, Daniel M. Kemp,