کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1938438 | 1050740 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons](/preview/png/1938438.png)
چکیده انگلیسی
In this paper, we investigated the action of huwentoxin-I (HWTX-I) purified from the venom of the Chinese bird spider Ornithoctonus huwena on Ca2+, Na+ channels of adult rat dorsal root ganglion (DRG) neurons. The results showed that huwentoxin-I could reduce the peak currents of N-type Ca2+ channels (IC50 ≈ 100 nM) and TTX-S Na+ channels (IC50 ≈ 55 nM), whereas no effect was detected on TTX-R Na+ channels. The comparative studies indicated that the selectivity of HWTX-I on Ca2+ channels was higher that of MVIIA and approximately the same as that of GVIA. HWTX-I is the first discovered toxin with the cross channel activities from the spider O. huwena venom similar to μ O-conotoxins MrVIA and MrVIB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 357, Issue 3, 8 June 2007, Pages 579–583
Journal: Biochemical and Biophysical Research Communications - Volume 357, Issue 3, 8 June 2007, Pages 579–583
نویسندگان
Meichi Wang, Xin Guan, Songping Liang,