کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1938549 | 1050742 | 2007 | 7 صفحه PDF | دانلود رایگان |

Phospholipase C (PLC) is a key enzyme in phosphoinositide signaling. We previously generated PLC-δ1 knockout (KO) mice and found that these mice showed remarkable hair loss caused by abnormalities in hair follicle structures. Here we show that the skin of PLC-δ1 KO mice displays typical inflammatory phenotypes, including increased dermal cellularity, leukocyte infiltration, and expression of pro-inflammatory cytokines. In addition, exogenously expressed PLC-δ1 attenuates lipopolysaccharide-induced expression of IL-1β, a pro-inflammatory cytokine, in an enzymatic activity-dependent manner. Furthermore, suppression of skin inflammation by anti-inflammatory reagents cured the epidermal hyperplasia in PLC-δ1 KO mice. Taken together, these results indicate that lack of PLC-δ1 induces skin inflammation and that the epidermal hyperplasia in PLC-δ1 KO mice is caused by skin inflammation. Our results also suggest that PLC-δ1 regulates homeostasis of the immune system in skin.
Journal: Biochemical and Biophysical Research Communications - Volume 356, Issue 4, 18 May 2007, Pages 912–918