کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1938917 1050750 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260
چکیده انگلیسی

Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 347, Issue 4, 8 September 2006, Pages 867–871
نویسندگان
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