کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1938991 | 1050751 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of IL-27p28 gene by lipopolysaccharide in dendritic DC2.4 cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation of IL-27p28 gene by lipopolysaccharide in dendritic DC2.4 cells Regulation of IL-27p28 gene by lipopolysaccharide in dendritic DC2.4 cells](/preview/png/1938991.png)
چکیده انگلیسی
To elucidate the regulation of IL-27p28 gene, we analyzed the promoter region of the gene in DC2.4 cells with or without lipopolysaccharide (LPS)-treatment. The results indicate that a region (−648 to −364) of p28 promoter was responsible for LPS-induction. EMSA with DNA probes within the region reveals that binding of GATA motif bound proteins was decreased by LPS-treatment. We identified one of the proteins as non-POU domain-containing octamer binding protein (NonO). Taken together, LPS-induced activation of IL-27p28 gene can be accounted for by the displacement of bound NonO protein from the IL-27p28 promoter.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 349, Issue 4, 3 November 2006, Pages 1372–1377
Journal: Biochemical and Biophysical Research Communications - Volume 349, Issue 4, 3 November 2006, Pages 1372–1377
نویسندگان
Maki Kamakura, Keiko Morisawa, Hideyuki Komi, Ayako Tomatani, Fumiji Saito, Yuko Konishi, Ya Jin, Takashi Manabe, Masayuki Kuroda, Shosuke Imai, Hiroyuki Mizuguchi, Taketoshi Taniguchi,