کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1938995 | 1050751 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases](/preview/png/1938995.png)
Nogo-A is a neurite outgrowth inhibitor protein associated with myelin in the central nervous system. Unexpectedly, targeted disruption of Nogo-A in mice results in little or no improvement of axonal regeneration, suggesting that Nogo-A has other functions and/or receives complex regulations to exert its inhibitory functions. Here, we have found that Nogo-A becomes phosphorylated at Tyr-694 in the N-terminal region. The phosphorylation is mediated co-operatively by Src-family tyrosine kinases, which play many important roles in the nervous system. Levels of tyrosine phosphorylation of Nogo-A seem to be irrelevant to developmental stages of oligodendrocytes, and might be regulated by specific extracellular stimuli. Identification of tyrosine phosphorylation of Nogo-A will introduce an additional level of complexity into Nogo-A functions.
Journal: Biochemical and Biophysical Research Communications - Volume 349, Issue 4, 3 November 2006, Pages 1401–1405