کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1939207 1050756 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanical strain-induced c-fos expression in pulmonary epithelial cell line A549
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Mechanical strain-induced c-fos expression in pulmonary epithelial cell line A549
چکیده انگلیسی

Pulmonary epithelial cells are exposed to mechanical strain during physiological breathing and mechanical ventilation. It was not clear which style was more related with cell mechanotransduction. c-fos is known to be a component of a transcription factor, activator protein-1, which is induced by oxidative stress. The regulatory pathways involved in the rapid response of the AP-1 transcription factor, c-fos, to mechanical load in the human pulmonary epithelial cell line A549 were investigated using a four-point bending model. In an effort to better understand what processes are involved in mechanotransduction, we have examined whether and how soon c-fos induction occurs in human A549 shortly after the application of the different mechanical strains stimuli.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 347, Issue 1, 18 August 2006, Pages 369–372
نویسندگان
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