کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1940596 | 1050784 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Replication-associated strand asymmetries in vertebrate genomes and implications for replicon size, DNA replication origin, and termination
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Replication-associated strand asymmetries in vertebrate genomes and implications for replicon size, DNA replication origin, and termination Replication-associated strand asymmetries in vertebrate genomes and implications for replicon size, DNA replication origin, and termination](/preview/png/1940596.png)
چکیده انگلیسی
Strand compositional asymmetry has been observed in prokaryotes and used in predicting prokaryotic DNA replication origins and termini. However, it was not found in eukaryotic genomes by the same methods. We propose that transcription-associated strand asymmetries mask the replication-associated ones. By analyzing the nucleotide composition of intergenic sequences larger than 50 kb by cumulative skew diagrams (CSD), we found replication-associated strand asymmetry in vertebrate genomes. Furthermore, we found that the most common replicon sizes in vertebrates are 50–100 kb, and show evidence that the replication origin and termination regions of vertebrate genomes range from a discrete site to a broad zone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 344, Issue 4, 16 June 2006, Pages 1258–1262
Journal: Biochemical and Biophysical Research Communications - Volume 344, Issue 4, 16 June 2006, Pages 1258–1262
نویسندگان
Wen-Ru Hou, Hai-Fang Wang, Deng-Ke Niu,