کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1940776 | 1050788 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We previously reported that deletion of the Fgf2 gene (Fgf2−/−) resulted in decreased bone mass in adult mice. This study examines the effect of haplo-insuffiency (Fgf2+/−) on bone loss in vertebrae from these mutant mice. Fgf2+/+ mice attained peak bone mass at 8–9 months of age. In contrast BMD was significantly reduced in vertebrae from adult (8–9) Fgf2+/− mice. Exogenous FGF-2 rescued reduced bone nodule formation in Fgf2+/− and Fgf2−/− cultures. Runx2 mRNA was reduced in cultures from Fgf2+/− and Fgf2−/− mice. FGF receptor2 mRNA and protein were markedly reduced in Fgf2+/− and Fgf2−/− mice. Decreased bone formation in Fgf2 mutant mice may correlate with impaired FGFR signaling, decreased Runx2 gene expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 339, Issue 2, 13 January 2006, Pages 490–498
Journal: Biochemical and Biophysical Research Communications - Volume 339, Issue 2, 13 January 2006, Pages 490–498
نویسندگان
T. Naganawa, L. Xiao, E. Abogunde, T. Sobue, I. Kalajzic, M. Sabbieti, D. Agas, M.M. Hurley,