کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1943041 | 1052642 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of calcium signalling by mitochondria
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
RyRIP3RSOCE[Ca2+]ERICRACMitochondrial Ca2+ concentration[Ca2+] - [Ca2 +][Ca2+]c - [Ca2 +] c[Ca2+]m - [Ca2 +] mSarcoplasmic reticulum - رتیکولوم سارکوپلاسمیکendoplasmic reticulum - شبکه آندوپلاسمی Cytosolic Ca2+ concentration - غلظت Ca2 + سیتواستولیCalcium concentration - غلظت کلسیمStore-operated Ca2+ entry - ورودی Ca2 + ذخیره شدهIP3 receptor - گیرنده IP3
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
In this review we will attempt to summarise the complex and sometimes contradictory effects that mitochondria have on different forms of calcium signalling. Mitochondria can influence Ca2+ signalling indirectly by changing the concentration of ATP, NAD(P)H, pyruvate and reactive oxygen species - which in turn modulate components of the Ca2+ signalling machinery i.e. buffering, release from internal stores, influx from the extracellular solution, uptake into cellular organelles and extrusion by plasma membrane Ca2+ pumps. Mitochondria can directly influence the calcium concentration in the cytosol of the cell by importing Ca2+ via the mitochondrial Ca2+ uniporter or transporting Ca2+ from the interior of the organelle into the cytosol by means of Na+/Ca2+ or H+/Ca2+ exchangers. Considerable progress in understanding the relationship between Ca2+ signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1787, Issue 11, November 2009, Pages 1374-1382
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1787, Issue 11, November 2009, Pages 1374-1382
نویسندگان
Ciara Walsh, Stephanie Barrow, Svetlana Voronina, Michael Chvanov, Ole H. Petersen, Alexei Tepikin,