کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1943041 | 1052642 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of calcium signalling by mitochondria
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کلمات کلیدی
RyRIP3RSOCE[Ca2+]ERICRACMitochondrial Ca2+ concentration[Ca2+] - [Ca2 +][Ca2+]c - [Ca2 +] c[Ca2+]m - [Ca2 +] mSarcoplasmic reticulum - رتیکولوم سارکوپلاسمیکendoplasmic reticulum - شبکه آندوپلاسمی Cytosolic Ca2+ concentration - غلظت Ca2 + سیتواستولیCalcium concentration - غلظت کلسیمStore-operated Ca2+ entry - ورودی Ca2 + ذخیره شدهIP3 receptor - گیرنده IP3
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Modulation of calcium signalling by mitochondria Modulation of calcium signalling by mitochondria](/preview/png/1943041.png)
چکیده انگلیسی
In this review we will attempt to summarise the complex and sometimes contradictory effects that mitochondria have on different forms of calcium signalling. Mitochondria can influence Ca2+ signalling indirectly by changing the concentration of ATP, NAD(P)H, pyruvate and reactive oxygen species - which in turn modulate components of the Ca2+ signalling machinery i.e. buffering, release from internal stores, influx from the extracellular solution, uptake into cellular organelles and extrusion by plasma membrane Ca2+ pumps. Mitochondria can directly influence the calcium concentration in the cytosol of the cell by importing Ca2+ via the mitochondrial Ca2+ uniporter or transporting Ca2+ from the interior of the organelle into the cytosol by means of Na+/Ca2+ or H+/Ca2+ exchangers. Considerable progress in understanding the relationship between Ca2+ signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1787, Issue 11, November 2009, Pages 1374-1382
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1787, Issue 11, November 2009, Pages 1374-1382
نویسندگان
Ciara Walsh, Stephanie Barrow, Svetlana Voronina, Michael Chvanov, Ole H. Petersen, Alexei Tepikin,