کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1944011 1053171 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
S. Typhimurium strategies to resist killing by cationic antimicrobial peptides
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
S. Typhimurium strategies to resist killing by cationic antimicrobial peptides
چکیده انگلیسی


• An effective outer membrane barrier is essential for evading the host immune system.
• Multiple regulatory systems control the remodel of the bacterial surface.
• Decreased negative charge prevents CAMP from binding to the bacterial surface.
• Proteolytic degradation and efflux systems inhibit CAMP from reaching its targets.

S. Typhimurium is a broad host range Gram-negative pathogen that must evade killing by host innate immune systems to colonize, replicate, cause disease, and be transmitted to other hosts. A major pathogenic strategy of Salmonellae is entrance, survival, and replication within eukaryotic cell phagocytic vacuoles. These phagocytic vacuoles and gastrointestinal mucosal surfaces contain multiple cationic antimicrobial peptides (CAMPs) which control invading bacteria. S. Typhimurium possesses several key mechanisms to resist killing by CAMPs which involve sensing CAMPs and membrane damage to activate signaling cascades that result in remodeling of the bacterial envelope to reduce its overall negative charge with an increase in hydrophobicity to decrease binding and effectiveness of CAMPs. Moreover Salmonellae have additional mechanisms to resist killing by CAMPs including an outer membrane protease which targets cationic peptides at the surface, and specific efflux pumps which protect the inner membrane from damage. This article is part of a Special Issue entitled: Bacterial Resistance to Antimicrobial Peptides.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1848, Issue 11, Part B, November 2015, Pages 3021–3025
نویسندگان
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