کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1944296 | 1053203 | 2013 | 7 صفحه PDF | دانلود رایگان |

• Three crown ether derivatives have been inserted into neutral liposomes.
• The effects of the guests on the bilayer have been studied by different techniques.
• Kinetic and thermodynamic profiles of mixed liposomes have been studied.
• In the presence of Ca2 + the crown ether lipids induce the DNA complexation.
Three crown ether derivatives, 1,2-O-dioleoyl-3-O-{2-[(12-crown-4)methoxy]ethyl}-sn-glycerol (12C4L), 1,2-O-dioleoyl-3-O-{2-[(15-crown-5)methoxy]ethyl}-sn-glycerol (15C5L) and 2,3-naphtho-15-crown-5 (NAP5), have been incorporated into 1-palmitoyl-2-oleoyl-phosphatydilcholine (POPC) liposomes. The size of the crown ether and the lipophilic moiety of 12C4L, 15C5L and NAP5 influence the stability and the properties of the extruded POPC liposomes determined at 25 °C in buffered aqueous solution at pH 7.4. The investigated liposomes are zwitterionic for POPC headgroups but can be turned into cationic aggregates in the presence of divalent cations. The capability of these systems to complex DNA has been demonstrated by SAXS experiments.
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Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1828, Issue 11, November 2013, Pages 2506–2512