Direct in vivo interaction of the antibiotic primycin with the plasma membrane of Candida albicans: An EPR study

► The antibiotic primycin as a membrane destructive agent. ► Primycin induced an increase of phase transition of membranes. ► Primycin caused slower molecular motions in membranes. ► Biological membranes divided into two distinct phase as a consequence of primycin. ► Fatty acids as the main target of primycin.