کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1945633 1053270 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The geometry of the ionic chànnel lumen formed by α-latroinsectotoxin from black widow spider venom in the bilayer lipid membranes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The geometry of the ionic chànnel lumen formed by α-latroinsectotoxin from black widow spider venom in the bilayer lipid membranes
چکیده انگلیسی

The dependence of single channel conductance formed by α-latroinsectotoxin (α-LIT) from black widow spider venom in the planar phospholipid membrane on the hydrodynamic radii of different nonelectrolytes allowed to determine the geometry of α-LIT water lumen. It was found that the cis- and trans-entrances of α-LIT channel had the same effective radii of 0.55–0.58 nm. Relatively small conductance of α-LIT channel (23.5 + 3.7 pS) in a symmetrical membrane bathing solution of 100 mM KCl (pH 7.4) may result from the constriction inside the channel with apparent radius of 0.37 nm located 32.5% of channel length away from the cis-entrance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1768, Issue 11, November 2007, Pages 2757–2763
نویسندگان
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