کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1946511 1537279 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic control of RNA polymerase I transcription in mammalian cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Epigenetic control of RNA polymerase I transcription in mammalian cells
چکیده انگلیسی

rRNA synthesis is regulated by genetic and epigenetic mechanisms. Epigenetic states are metastable, changing in response to appropriate signals, thereby modulating transcription in vivo. The establishment, maintenance and reversal of epigenetic features are fundamental for the cell's ability to ‘remember’ past events, to adapt to environmental changes or developmental cues and to propagate this information to the progeny. As packaging into chromatin is critical for the stability and integrity of repetitive DNA, keeping a fraction of rRNA genes in a metastable heterochromatic conformation prevents aberrant exchanges between repeats, thus safeguarding nucleolar structure and rDNA stability. In this review, we will focus on the nature of the molecular signatures that characterize a given epigenetic state of rDNA in mammalian cells, including noncoding RNA, DNA methylation and histone modifications, and the mechanisms by which they are established and maintained. This article is part of a Special Issue entitled: Transcription by Odd Pols.


► Reviews structural features of active, silent and poised rRNA genes.
► Describes the pathways that establish distinct epigenetic states of rRNA genes.
► Highlights the role of noncoding RNA in epigenetic regulation.
► Discusses the impact of external signals on epigenetic regulation of rRNA synthesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1829, Issues 3–4, March–April 2013, Pages 393–404
نویسندگان
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