Mammalian alphaherpesvirus miRNAs

► We review the published literature on mammalian alphaherpesviruses and microRNAs. ► So far, five of these viruses are known to express microRNAs. ► The most is known about herpes simplex virus microRNAs. ► Some microRNAs are expressed abundantly during latent infections of sensory neurons. ► Transfection studies suggest some microRNAs might promote latency. ► Overall, we know little about microRNA targets and roles in virus infection.