کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1947187 1537322 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of Smad activities
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Regulation of Smad activities
چکیده انگلیسی

TGF-β (Transforming Growth Factor-β) cytokines employ Smad proteins as the intracellular mediator of signaling. Upon TGF-β stimulation, the cytoplasmic Smads become phosphorylated and consequently accumulate in the nucleus to regulate target gene expression. The cytoplasm-to-nucleus redistribution of Smads, as well as the ability of Smads to activate or repress gene transcription, is under multiple layers of regulation by factors not limited to TGF-β. With recent advance in the knowledge of regulatory factors impinged on Smads, we are beginning to understand the complexity in cellular responses to TGF-β.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression - Volume 1759, Issues 11–12, November–December 2006, Pages 503–513
نویسندگان
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