Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells

► Orai1/CRACM1 overexpression resulted in the reduction of cell proliferation ► Phosphorylation of ERK1/2 and Akt is blocked by Orai1/CRACM1 overexpression. ► Orai1/CRACM1 overexpression resulted in a cell cycle G0/G1 phase arrest. ► Store-operated calcium inhibitors influenced cell proliferation.