کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1947956 1054664 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nuclear ferritin: A new role for ferritin in cell biology
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Nuclear ferritin: A new role for ferritin in cell biology
چکیده انگلیسی

BackgroundFerritin has been traditionally considered a cytoplasmic iron storage protein. However, several studies over the last two decades have reported the nuclear localization of ferritin, specifically H-ferritin, in developing neurons, hepatocytes, corneal epithelial cells, and some cancer cells. These observations encouraged a new perspective on ferritin beyond iron storage, such as a role in the regulation of iron accessibility to nuclear components, DNA protection from iron-induced oxidative damage, and transcriptional regulation.Scope of ReviewThis review will address the translocation and functional significance of nuclear ferritin in the context of human development and disease.Major conclusionsThe nuclear translocation of ferritin is a selective energy-dependent process that does not seem to require a consensus nuclear localization signal. It is still unclear what regulates the nuclear import/export of ferritin. Some reports have implicated the phosphorylation and O-glycosylation of the ferritin protein in nuclear transport; others suggested the existence of a specific nuclear chaperone for ferritin. The data argue strongly for nuclear ferritin as a factor in human development and disease. Ferritin can bind and protect DNA from oxidative damage. It also has the potential of playing a regulatory role in transcription.General significanceNuclear ferritin represents a novel new outlook on ferritin functionality beyond its classical role as an iron storage molecule.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1800, Issue 8, August 2010, Pages 793–797
نویسندگان
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