کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1948077 1054674 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PGC-1α in aging and anti-aging interventions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
PGC-1α in aging and anti-aging interventions
چکیده انگلیسی

Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction — a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1α is a critical regulator of mitochondrial energy metabolism and biogenesis. PGC-1α is uniquely poised as a potential target for correcting the effects of age on mitochondrial decline. We describe the cellular and tissue specific mechanisms of PGC-1α regulation and illustrate how these pathways may be involved in the aging process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1790, Issue 10, October 2009, Pages 1059–1066
نویسندگان
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