کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1949150 1537723 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein
ترجمه فارسی عنوان
پسوریازیس خواص ضد اکسیداسیون و ضد التهاب لیپوپروتئین با چگالی بالا را کاهش می دهد
کلمات کلیدی
پسوریازیس، لیپوپروتئین با چگالی بالا، اموال ضد اکسیداتیو، ضد التهاب
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Psoriatic high-density lipoprotein was decreased in functional properties of anti-inflammation, anti-oxidation and anti-apoptosis.
• Psoriatic low-density lipoprotein was aggravated in functional properties of pro-inflammation and pro-oxidation.
• The malondialdehyde content in high-density lipoprotein and in low-density lipoprotein were increased.

Psoriasis is a chronic inflammatory skin disease, which has been linked to dyslipidemia with potential functional impairment of lipoproteins. This cross-sectional study was designed to characterize the biological activities of plasma lipoproteins in 25 patients with psoriasis and 25 age- and sex-matched healthy controls.In the present study, we found that plasma levels of high-density lipoprotein (HDL) cholesterol were decreased in the psoriasis group compared to healthy controls. The malondialdehyde (MDA) content in plasma, in HDL3 and in low-density lipoprotein (LDL) were increased. However, the activity of plasma paraoxonase-1 (PON-1) decreased in psoriasis and negatively correlated with the psoriasis area and severity index (PASI). Moreover, plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were increased in psoriasis and positively correlated with the PASI. High-sensitivity C-reactive protein (hs-CRP) was increased in psoriasis, but did not reach significance when correlated with PASI. In vitro tests displayed that the functionalities of HDL3 isolated from psoriatic patients significantly decreased, which were assessed in four independent ways, namely (1) protection against LDL oxidation, (2) inhibition of tumor necrosis factor-α (TNF-α) induced monocyte adherence to endothelial cells, (3) prevention of oxidized low density lipoprotein (ox-LDL) induced monocyte migration, and (4) protection of endothelial cells from TNF-α induced apoptosis. Further, pro-oxidative and pro-inflammatory properties of LDL isolated from psoriatic patients were increased. In conclusion, the biological activities of psoriatic lipoproteins are impaired in both HDL and LDL, which may provide a link between psoriasis and cardiovascular disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 12, December 2014, Pages 1709–1715
نویسندگان
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