کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1949155 | 1537723 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length
ترجمه فارسی عنوان
جذب اسید های کبدی توسط طول زنجیره آکیل زدایی آلفا تنظیم می شود
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کلمات کلیدی
SLSFATPFABPpmCerSDRMSVLCFABPCD36/FATNAFLDplasma membrane fatty acid binding proteinHFDSSOLCFAFFAsphingolipids - اسفنگولیپیدsphingolipid - اسپینگولایپیدFree fatty acid - اسید چرب آزادlong chain fatty acid - اسید چرب زنجیره طولانیfatty acid translocase - انتقال پروتئین اسید چربNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیtriacylglycerol - تری آسیل گلیسرول Fatty acid uptake - جذب اسید چربcluster of differentiation 36 - خوشه تمایز 36High fat diet - رژیم غذایی با چربی بالاceramide synthase - سنتاز سرامیدDetergent resistant membranes - غشای مقاوم در برابر مواد شویندهFatty acid binding protein - پروتئین اتصال دهنده اسید چربFatty acid transport protein - پروتئین حمل و نقل اسید چرب
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Ceramide synthase 2 (CerS2) null mice cannot synthesize very-long acyl chain (C22-C24) ceramides resulting in significant alterations in the acyl chain composition of sphingolipids. We now demonstrate that hepatic triacylglycerol (TG) levels are reduced in the liver but not in the adipose tissue or skeletal muscle of the CerS2 null mouse, both before and after feeding with a high fat diet (HFD), where no weight gain was observed and large hepatic nodules appeared. Uptake of both BODIPY-palmitate and [3H]-palmitate was also abrogated in the hepatocytes and liver. The role of a number of key proteins involved in fatty acid uptake was examined, including FATP5, CD36/FAT, FABPpm and cytoplasmic FABP1. Levels of FATP5 and FABP1 were decreased in the CerS2 null mouse liver, whereas CD36/FAT levels were significantly elevated and CD36/FAT was also mislocalized upon insulin treatment. Moreover, treatment of hepatocytes with C22-C24-ceramides down-regulated CD36/FAT levels. Infection of CerS2 null mice with recombinant adeno-associated virus (rAAV)-CerS2 restored normal TG levels and corrected the mislocalization of CD36/FAT, but had no effect on the intracellular localization or levels of FATP5 or FABP1. Together, these results demonstrate that hepatic fatty acid uptake via CD36/FAT can be regulated by altering the acyl chain composition of sphingolipids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 12, December 2014, Pages 1754-1766
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 12, December 2014, Pages 1754-1766
نویسندگان
Woo-Jae Park, Joo-Won Park, Alfred H. Jr., Judith Storch, Yael Pewzner-Jung, Anthony H. Futerman,