Lipid-dependent protein sorting at the trans-Golgi network

► This review highlights lipid involvement in membrane sorting at the TGN. ► Data support the role of lipid rafts in cargo segregation and carrier formation. ► Clustering of lipid rafts is a prerequisite for these processes. ► Clustering and carrier formation is supported by auxiliary proteinous factors. ► Fine tuning of lipid composition is likely to further regulate these processes.