H2O2 disposal in cardiolipin-enriched brain mitochondria is due to increased cytochrome c peroxidase activity

►Phospholipids fused to brain mitochondria do not alter respiration. ►Fused cardiolipin favours H2O2 elimination through cyt c peroxidase activity. ►Cyt c-dependent cardiolipin peroxidation favours cyt c release. ►Phosphatidylserine decreases H2O2 independently of cyt c.