1α,25-Dihydroxyvitamin D3 exerts tissue-specific effects on estrogen and androgen metabolism

►1α,25-Dihydroxyvitamin D3 alters sex hormone metabolism in a cell line-specific way. ►1α,25-Dihydroxyvitamin D3 increases androgen production in breast cancer MCF-7 cells. ►1α,25-Dihydroxyvitamin D3 increases aromatase expression in LNCaP and H295R cells. ►Adds data supporting that vitamin D acts as a selective aromatase modulator ►New data important in the discussion of H295R as a model for sex hormone metabolism