A physiologically-based kinetic model for the prediction of plasma cholesterol concentrations in the mouse

► We model the intake, synthesis, transport, and degradation of cholesterol in mice. ► The model constructed can predict plasma cholesterol concentrations in knockout mice. ► A good prediction was given for 14 knockout strains, including Ldlr−/− and Apoe−/−. ► The model hints cholesterol transport to HDL to be independent on liver cholesterol.