کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1949925 1537788 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biogenesis of cytoplasmic lipid droplets: From the lipid ester globule in the membrane to the visible structure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Biogenesis of cytoplasmic lipid droplets: From the lipid ester globule in the membrane to the visible structure
چکیده انگلیسی

The cytoplasmic lipid droplet (CLD) and very low-density lipoprotein are generated from the lipid ester synthesized in the endoplasmic reticulum. The lipid ester deposited between the two membrane leaflets is supposed to bulge toward the cytoplasm to make a nascent CLD, but its size must be below the resolution limit of conventional techniques and the detectable CLD should only form after acquisition of additional lipid esters. The CLD is different from vesicular organelles in that the internal content is highly hydrophobic and the shape is invariably spherical. Due to its unique characteristics, quantitative discordance between the surface and the volume may occur in the growth and/or involution processes of the CLD. The possibility that these processes may give rise to the structural and functional diversities of the CLD is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1791, Issue 6, June 2009, Pages 399–407
نویسندگان
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