کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1949962 1537796 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sphingosine-1-phosphate regulation of mammalian development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Sphingosine-1-phosphate regulation of mammalian development
چکیده انگلیسی

Sphingosine-1-phosphate (S1P) was first identified as a lysophospholipid metabolite whose formation is required for the irreversible degradation of sphingolipids. Years later, it was discovered that S1P is a bioactive lipid that provokes varied cell responses by acting through cell-surface receptors to drive cell signaling. More recent findings in model organisms have now established that S1P metabolism and signaling are integrated into many physiological systems. We describe here the surprising breadth of function of S1P in mammalian development and the underlying biologic processes that S1P regulates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1781, Issue 9, September 2008, Pages 435–441
نویسندگان
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