کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950236 1537819 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Membrane binding and subcellular targeting of C2 domains
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Membrane binding and subcellular targeting of C2 domains
چکیده انگلیسی

C2 domains are a ubiquitous structural module and many of them function in Ca2+-dependent membrane binding and thereby serve as Ca2+ effectors for divergent Ca2+-mediated cellular processes. Extensive structural, biochemical, biophysical, and cellular studies of C2 domains and host proteins in the past decade have shown that due to their structural diversity C2 domains have disparate Ca2+ sensitivity, lipid selectivity and membrane binding mechanisms. This review summarizes the basic structural and functional properties of C2 domains as well as recent findings on Ca2+ and membrane binding, lipid selectivity, and subcellular localization of C2 domains and their host proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1761, Issue 8, August 2006, Pages 838–849
نویسندگان
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