کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950591 1055671 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular interplay in pulmonary arterial hypertension: Implications for new therapies
ترجمه فارسی عنوان
اثر متقابل سلولی در فشار خون بالا در شریان ریوی: اثرات درمان های جدید
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• We review the molecular and cellular pathways underlying PAH pathogenesis.
• The interaction between vascular cells underlines PAH development and progression.
• BMP signaling pathway has a vast contribution to PAH-related cellular interplay.
• Novel therapies focus in inflammation, proliferation and platelet dysfunction.

Pulmonary arterial hypertension (PAH) is a complex and multifactorial disease characterized by vascular remodeling, vasoconstriction, inflammation and thrombosis. Although the available therapies have resulted in improvements in morbidity and survival, PAH remains a severe and devastating disease with a poor prognosis and a high mortality, justifying the need of novel therapeutic targets. An increasing number of studies have demonstrated that endothelial cells (ECs), smooth muscle cells (SMCs) and fibroblasts of the pulmonary vessel wall, as well as platelets and inflammatory cells have a role in PAH pathogenesis. This review aims to integrate the interplay among different types of cells, during PAH development and progression, and the impact of current therapies in cellular modulation. The interplay among endothelial cells, smooth muscle cells and fibroblasts present in pulmonary vessels wall, platelets and inflammatory cells is regulated by several mediators produced by these cells, contributing to the pathophysiologic features of PAH. Current therapies are mainly focused in the pulmonary vascular tone and in the endothelial dysfunction. However, once they have not been effective, novel therapies targeting other PAH features, such as inflammation and platelet dysfunction are emerging. Further understanding of the interplay among different vascular cell types involved in PAH development and progression can contribute to find novel therapeutic targets, decreasing PAH mortality and morbidity in the future.

Figure optionsDownload high-quality image (119 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1843, Issue 5, May 2014, Pages 885–893
نویسندگان
, , ,