کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950655 1537957 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The emerging multiple roles of nuclear Akt
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The emerging multiple roles of nuclear Akt
چکیده انگلیسی

Akt is a central player in the signal transduction pathways activated in response to many growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of cellular functions including proliferation and survival, autophagy, metabolism, angiogenesis, motility, and exocytosis. Moreover, dysregulated Akt activity is being implicated in the pathogenesis of a growing number of disorders, including cancer. Evidence accumulated over the past 15 years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways. For example, nuclear Akt counteracts apoptosis through a block of caspase-activated DNase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mRNA: messenger RNA export, DNA repair, and tumorigenesis. In this review, we shall summarize the most relevant findings about nuclear Akt and its functions.


► Discussed the latest research on nuclear Akt
► Special emphasis is placed on anti-apoptotic signaling controlled by nuclear Akt.
► Nuclear Akt-interacting proteins control key processes.
► Intranuclear p-Akt levels are emerging as a predictor of tumor prognosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1823, Issue 12, December 2012, Pages 2168–2178
نویسندگان
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