کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950702 1055692 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ferroportin-mediated iron transport: Expression and regulation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Ferroportin-mediated iron transport: Expression and regulation
چکیده انگلیسی

The distinguishing feature between iron homeostasis in single versus multicellular organisms is the need for multicellular organisms to transfer iron from sites of absorption to sites of utilization and storage. Ferroportin is the only known iron exporter and ferroportin plays an essential role in the export of iron from cells to blood. Ferroportin can be regulated at many different levels including transcriptionally, post-transcriptionally, through mRNA stability and post-translationally, through protein turnover. Additionally, ferroportin may be regulated in both cell-dependent and cell-autonomous fashions. Regulation of ferroportin is critical for iron homeostasis as alterations in ferroportin may result in either iron deficiency or iron overload. This article is part of a Special Issue entitled: Cell Biology of Metals.


► Ferroportin is the only known iron exporter.
► Malregulation of ferroportin leads to human disease, iron limitation or iron overload.
► Ferroportin is regulated transcriptionally, post-transcriptionally, and post-translationally.
► Post-translational regulation can occur by hepcidin-dependent and hepcidin-independent mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1823, Issue 9, September 2012, Pages 1426–1433
نویسندگان
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