کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950815 1055713 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
How viruses access the nucleus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
How viruses access the nucleus
چکیده انگلیسی

Many viruses depend on nuclear proteins for replication. Therefore, their viral genome must enter the nucleus of the host cell. In this review we briefly summarize the principles of nucleocytoplasmic transport, and then describe the diverse strategies used by viruses to deliver their genomes into the host nucleus. Some of the emerging mechanisms include: (1) nuclear entry during mitosis, when the nuclear envelope is disassembled, (2) viral genome release in the cytoplasm followed by entry of the genome through the nuclear pore complex (NPC), (3) capsid docking at the cytoplasmic side of the NPC, followed by genome release, (4) nuclear entry of intact capsids through the NPC, followed by genome release, and (5) nuclear entry via virus-induced disruption of the nuclear envelope. Which mechanism a particular virus uses depends on the size and structure of the virus, as well as the cellular cues used by the virus to trigger capsid disassembly and genome release. This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import.

Research Highlights
► Many viruses must access the nucleus of the host cell.
► Five strategies have been identified for viral nuclear access.
► These involve waiting for mitosis or using the host nuclear transport machinery.
► A newly identified strategy involves disrupting the nuclear envelope.
► The strategy used depends on the size and structure of the virus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1813, Issue 9, September 2011, Pages 1634–1645
نویسندگان
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