کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1952494 1057212 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular property–binding affinity relationship of flavonoids for common rat plasma proteins in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Molecular property–binding affinity relationship of flavonoids for common rat plasma proteins in vitro
چکیده انگلیسی

The structural difference of flavonoids strongly affects the binding process with plasma proteins. This work in here mainly concerns about the molecular property–binding affinity relationship of dietary flavonoids for common rat plasma proteins (CRPP). The magnitudes of binding constants between flavonoids and CRPP were within the range of 104–105 L/mol and the number of binding sites (n) was determined as 1.02 ± 0.19. These data were much smaller than the affinities between flavonoids and purified bovine and human serum albumins. The hydroxylation on rings A, B and C of flavonoids significantly affected the binding affinity. The glycosylation of dietary flavonoids decreased the binding affinity and the C2C3 double bond hardly affected it. The galloylated catechins have higher binding affinities for CRPP than non-galloylated catechins. Flavonoids played as a hydrogen bond acceptor when bound to CRPP. The flavonoids with high topological polar surface areas (TPSA) are bound tightly while those with low TPSA are not.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 93, Issue 2, February 2011, Pages 134–140
نویسندگان
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