کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1953126 1057252 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
چکیده انگلیسی

IMGT®, the international ImMunoGeneTics information system® (http://imgt.cines.fr), is the reference in immunogenetics and immunoinformatics. IMGT standardizes and manages the complex immunogenetic data which include the immunoglobulins (IG) or antibodies, the T cell receptors (TR), the major histocompatibility complex (MHC) and the related proteins of the immune system (RPI) which belong to the immunoglobulin superfamily (IgSF) and the MHC superfamily (MhcSF). The accuracy and consistency of IMGT data and the coherence between the different IMGT components (databases, tools and Web resources) are based on IMGT-ONTOLOGY, the first ontology for immunogenetics and immunoinformatics. IMGT-ONTOLOGY manages the immunogenetics knowledge through diverse facets relying on seven axioms, “IDENTIFICATION”, “DESCRIPTION”, “CLASSIFICATION”, “NUMEROTATION”, “LOCALIZATION”, “ORIENTATION” and “OBTENTION”, that postulate that objects, processes and relations have to be identified, described, classified, numerotated, localized, orientated, and that the way they are obtained has to be determined. These axioms constitute the Formal IMGT-ONTOLOGY, also designated as IMGT-Kaleidoscope. Through the example of the IG molecular synthesis, the concepts generated from the “IDENTIFICATION”, “DESCRIPTION”, “CLASSIFICATION” and “NUMEROTATION” axioms are detailed with their main instances and semantic relations. The axioms have been essential for the conceptualization of the molecular immunogenetics knowledge and can be used to generate concepts for multi scale approaches at the molecule, cell, tissue, organ, organism or population level, emphasizing the generalization of the application domain. In that way the Formal IMGT-ONTOLOGY represents a paradigm for the elaboration of ontologies in system biology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 90, Issue 4, April 2008, Pages 570–583
نویسندگان
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