Osteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast

► Salubrinal differentially regulates osteoblast and osteoclast differentiations. ► eIF2α phosphorylation down-regulates NFATc1 during RANKL induced osteoclastogenesis. ► ATF4 up-regulation contributes osteoblast differentiation in response to salubrinal. ► Salubrinal prevents bone destruction induced by RANKL in vivo.