Adenovirus-mediated tissue factor pathway inhibitor gene transfer induces apoptosis by blocking the phosphorylation of JAK-2/STAT-3 pathway in vascular smooth muscle cells

► TFPI played an apoptosis-inducing role in VSMCs. ► TFPI might induce VSMCs apoptosis by inhibiting JAK-2/STAT-3 pathway phosphorylation. ► The down-regulation of survivin might be involved in TFPI induced apoptosis in VSMCs.