The iron status of a healthy South African adult population

• In a study of 651 healthy South African adult participants, the prevalence of anaemia was 12.6%
• Iron deficiency, as determined by a ferritin level of < 30 μg/L, was found in 39.8% of participants.
• The prevalence of iron deficiency with anaemia was 9.8% whereas 30% had iron deficiency without anaemia.
• Iron deficiency anaemia was more prevalent in females and Black Africans.

IntroductionIron deficiency is associated with significant morbidity and mortality, can present with or without haematological changes and is a major cause of microcytic anaemia. In South Africa and Africa in general, there is a paucity of studies on the iron status of healthy adult non pregnant females and males > 18 years of age. The aim of the study was to determine the prevalence of iron deficiency in a healthy South African population.MethodsA total of 651 healthy adults > 18 years were included in the study. Blood samples were taken for the determination of iron status, haematological and inflammatory parameters. A ferritin level of < 30 μg/L was used to define iron deficiency and these subjects were further divided into those with and without anaemia. Diet and menstrual history in females was further investigated.ResultsOverall, the prevalence of anaemia was 12.6% and iron deficiency was found in 78% of anaemic subjects. The prevalence of iron deficiency was 39.8% in all participants and females and Black Africans had a very high prevalence of 56.6% and 50.7% respectively. Significant (p < 0.05) differences were found in concentrations of ferritin, haemoglobin, iron, transferrin, transferrin saturation, MCV and MCH between the groups.ConclusionAnaemia is a minor health problem but a large proportion of subjects with iron deficiency do not present with anaemia. The prevalence of iron deficiency was high especially in females and Black African participants.