کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965059 1538638 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum phosphorus, cardiovascular and all-cause mortality in the general population: A meta-analysis
ترجمه فارسی عنوان
فسفر سرم، مرگ و میر قلبی عروقی و همه موارد در جمعیت عمومی: یک متاآنالیز
کلمات کلیدی
فسفر سرم، فسفات سرم، مرگ و میر قلب و عروق، مرگ و میر همه موارد، متا تجزیه و تحلیل
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Findings on serum phosphorus concentration and mortality risk are conflicting.
• Higher serum phosphorus significantly increased cardiovascular and all-cause mortality risk
• All-cause mortality risk appears to be more pronounced in men but not women.

BackgroundThe association between elevated serum phosphorus concentration and cardiovascular or all-cause mortality yielded conflicting results.ObjectiveTo assess the association between elevated serum phosphorus concentration and cardiovascular or all-cause mortality in the general population by conducting a meta-analysis.MethodsWe systematically searched the Pubmed and Embase databases until March 2016 for the prospective studies investigating serum phosphorus concentration and cardiovascular or all-cause mortality in the general population. We pooled risk ratio (RR) and corresponding 95% confidence intervals (CI) for the highest versus the reference category of serum concentration of phosphorus.ResultsSix prospective cohort studies involving 120,269 subjects were identified.When compared the highest with the reference concentration of serum phosphorus, the pooled RR of cardiovascular mortality and all-cause mortality were 1.36 (95% CI 1.07–1.72) and 1.35 for all-cause mortality (95% CI 1.15–1.58), respectively. Stratified analyses revealed that elevated serum phosphorus significantly increased all-cause mortality risk among men (RR 1.33; 95% CI 1.11–1.60), but not in women (RR 1.09; 95% CI 0.89–1.33).ConclusionsElevated serum phosphorus concentration is independently associated with excessive risk of cardiovascular and all-cause mortality in the general population without chronic kidney disease. Serum phosphorus on all-cause mortality risk appears to be pronounced in men but exhibits no clear effect on women. However, gender difference of elevated serum phosphorus on mortality risk should be verified by more prospective studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 461, 1 October 2016, Pages 76–82
نویسندگان
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